细胞自吞噬是胞内主要的降解系统，胞质物质可籍此系统被转运至溶酶体内降解清除。但吞噬的目的并非仅限于此，而是作为一个动态循环系统，为细胞更新和稳态维持生产构件物质和能量。本文从多学科的角度，对当前自吞噬在代谢调控、胞内质量平衡以及发育和分化过程更新中所扮演的角色等方面所取得的最新进展进行了综述。本文作者也探讨了近期小鼠模型与人类遗传学研究进展，对认识细胞自吞噬的活化或损害在不同病理过程中的作用等方面的帮助。这些疾病包括从神经退行性疾病如帕金森综合症到Crohn 症等炎症的多种疾病。

Autophagy is themajor intracellular degradation systembywhich cytoplasmicmaterials are deliveredto and degraded in the lysosome. However, the purpose of autophagy is not the simple elimination of materials, but instead, autophagy serves as a dynamic recycling system that produces new building blocks and energy for cellular renovation and homeostasis. Here we provide a multidisciplinary review of our current understanding of autophagy’s role inmetabolic adaptation, intracellular quality control, and renovation during development and differentiation. We also explore how recent mouse models in combination with advances in human genetics are providing key insights into how the impairment or activation of autophagy contributes to pathogenesis of diverse diseases, fromneurodegenerative diseases such as Parkinson disease to inflammatory disorders such as Crohn disease.

阅读全文，请链接:  http://www.cell.com/abstract/S0092-8674(11)01276-1

细胞自噬研究产品：http://www.enzolifesciences.com/welcome/comprehensive-solutions-for-autophagy/